The objective of this study was to investigate the in vivo activity of the lantibiotic lacticin 3147 against the luminescent\nStaphylococcus aureus strain Xen 29 using a murine model. Female BALB/c mice (7 weeks old, 17 g) were divided into groups\n(n = 5) and infected with the Xen 29 strain via the intraperitoneal route at a dose of 1 Ã?â?? 106 cfu/animal. After 1.5 hr, the animals\nwere treated subcutaneously with doses of phosphate-buffered saline (PBS; negative control) or lacticin 3147. Luminescent imaging\nwas carried 3 and 5 hours postinfection.Mice were then sacrificed, and the levels of S. aureus Xen 29 in the liver, spleen, and kidneys\nwere quantified. Notably, photoluminescence and culture-based analysis both revealed that lacticin 3147 successfully controlled\nthe systemic spread of S. aureus in mice thus indicating that lacticin 3147 has potential as a chemotherapeutic agent for in vivo\napplications.
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